Key benefits for research foundations
- Capture and organize fragmented data dispersed across multiple laboratories.
- Easily set-up and manage collaborations involving multiple research groups located anywhere in the world.
- Enable new research paradigms that maximize the benefits of highly-interactive collaborations.
- Ensure continued access to the results of sponsored research by archiving all research data in a central, secure, industrial-strength database.
- Integrate dispersed efforts: test Group A's compounds with Group B's models against Group C's new target.
- Maintain research continuity as the research groups participating in a collaborative project change.
- Avoid performing redundant research work.
- Avoid the need to purchase and maintain hardware and software, avoid the need to pay an IT specialist to support users, and avoid the need to worry about the security and integrity of research data.
- Exploit state-of-the-art database software and support at an affordable price.
- Protect the commercial value inherent in the research data your foundation sponsors, so promising approaches can be patented and commercialized, while also encouraging researchers to share data to the greatest extent practical.
- Extract the greatest value from preclinical data to advance new drugs more rapidly.
Additional benefits by specialty or specific need
Key benefits for chemists »
- Easily upload and register chemical structures into the database. Biologists can separately upload bioassay data. The results will correlate automatically via common structure names or other unique identifiers you specify.
- Exploit intelligent structure-aware search tools. The intuitive interface will guide you if you have little or no prior experience with sophisticated informatics tools. If you're already an expert, you will appreciate powerful features such as sub-structure and similarity searching.
- See Lipinski Rule violations and standard physical-chemical properties at a glance.
- View chemical structures in 2D or 3D and edit them to compose new structure-based searches, or use SMILES strings if you prefer.
Key benefits for biologists »
- Easily upload enzyme, cell, and animal bioactivity data as well as PK/PD/ADME/Tox data into the database. Chemists can separately upload chemical structures. The results will correlate automatically via common structure names or other unique identifiers you specify.
- Export structures and assay data to an Excel file with just two quick clicks.
- Customize your protocols and define your own preclinical SAR templates. CDD's software adapts to your group's needs rather than force you to adopt a new workflow.
- Automate the ingestion of HTS data.
- Search by any attribute, including bioactivity, potency and selectivity data, structure-activity relationships, pattern recognition, Boolean searches, modeling and more.
- Visualize plate data with heatmaps and scatterplots for hit-to-lead identification, high-content screens, and multi-dimensional data.
Key benefits for neglected disease researchers »
- Join existing communities organized around therapeutic or target areas, or start a new one.
- Augment your research data with extensive research data curated by CDD from the scientific literature as well as data shared openly and directly from the laboratories of leading scientists.
- Exploit state-of-the-art database software and support at an affordable price.
- Build highly-networked virtual drug discovery and development communities.
- Bridge the complementary disciplines of biology, chemistry, computational chemistry, and medicinal chemistry to advance new leads more effectively.
- Maintain research continuity as the research groups participating in a collaborative project change.
- Ensure continued access to the results of joint research activities by archiving all research data in a central, industrial-strength database.
- Enable new research paradigms that maximize the benefits of highly-interactive collaborations.
- Easily set-up and manage collaborations involving multiple research groups located anywhere in the world.
- Protect the commercial value inherent in the research data you generate, so promising approaches can be patented and commercialized, while also encouraging colleagues to share data to the greatest extent practical.
I am screening libraries and need a more robust repository for my data than reams of Excel spreadsheets »
CDD gives you all the advantages of an industrial-strength database...
- reliability
- data integrity
- organization
- heterogeneous data formats
- mining across all data sets
but with the ease of use and flexibility associated with Excel files. The CDD database easily imports from and exports to Excel, CSV, SD, and SDF files.
I am in a collaboration and want to see my colleagues' data in real time »
- All your data always remain private by default. The CDD database also allows you to share your private data and protocols selectively with colleagues you specify.
- The CDD database allows all group members and authorized collaborators to see data as they are updated. Collaborators can be across the hallway, or across the world.
- The CDD database differs from other collaboration tools in that it designed specifically to manage and search preclinical research data (including both biology and chemistry data).
- Other companies offer similar database products, but they are not designed to support collaborations. (They are also expensive and difficult to support.)
I already have an in-house database from another vendor, but it's too expensive and too hard to use »
- The CDD database is industrial-strength software priced to be affordable for academic laboratories and corporate research labs.
- There's nothing to install or update, just log in securely from any computer (Windows, Mac, Linux) and go.
- Your data is automatically encrypted and backed up securely and privately to multiple redundant sites hosted by CDD.
- There's no hardware to maintain, no software to update, and no need to pay an IT specialist.
- CDD provides full customer support no matter how large or small your organization is.
- The web-based interface is intuitively organized, enabling new users (including students) to get started with minimal training.
Case #1: Pathbreaking research foundation
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Challenge:
The foundation supports research groups spanning several disciplines (small molecule synthesis, animal studies, cell biology, etc.) in a tightly focused effort to develop new treatments for a debilitating disease.
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Specific Problems:
The foundation's research model encourages interdisciplinary collaboration, but scientists have difficulty fully exploiting each other's data because they approach common problems from different perspectives. The various participating research groups all rely on different hardware and software, and they are wary of conventional database tools, which require an enormous investment of time to train users. As the composition of the research portfolio changes, the foundation needs to retain and manage previous results so ongoing research can build upon them. The foundation also needs to protect the commercial value inherent in the research data, so promising approaches can be patented and commercialized.
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CDD's database solved these problems:
The CDD database combines the intuitive ease-of-use of a web browser with the industrial-strength reliability of a conventional database. Hyperlinks steer users where they need to go. A synthetic chemist can upload her data while a toxicologist can easily add his screening results without needing to know the details of the chemical structures. CDD's database is easy to start using, so researchers readily adopt it as part of a productive workflow rather than view it as a chore. The foundation can easily retain and protect data and support a seamless workflow among its geographically dispersed collaborators.
