You can now choose a different level of aggregation for each average readout, whereas previously the aggregation level was uniformly set for all readout definitions in the vault.
The available aggregation levels are as follows:
The calculation of averages is now a separate step: you have to create the readout definitions you want to average first, then click “add calculated readout definition”.
Once you’ve configured an average readout definition, you will see it listed right next to the corresponding non-averaged definition on the protocol page (below), in search results, and on the run page’s data tab. Note that you can not yet average normalized or dose-response readout definitions.
While positive controls are almost always a good idea, some assays are run without them. Until now, dose-response calculations required both a positive and a negative control if the raw data was to be automatically normalized within the CDD Vault. In this release you can normalize your dose-response data as percent of negative control. You will see the new option when you define a dose-response calculation in your protocol:
The “description” field, which was previously part of the core molecule definition, is now just another user-defined field. If you had any data in the description field, it was automatically migrated.
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