From the desk of Sean Ekins, CSO
Yesterday I attended the Ninth Chapel Hill Pharmaceutical Sciences Conference which was co-sponsored by CDD. I was not alone as there was a large audience of graduate and post graduate students and professors, easily in excess of 250.
We were treated to 8 exceptional talks from luminaries in the field of chemical biology as follows.
Kevan Shokat (UCSF) – Nontraditional approaches to drugging traditional targets: kinases and GTPases
Tom Muir (Princeton University) – Painting Chromatin with synthetic protein chemistry
Donald McDonnell (Duke University) – ERRα regulated lactate metabolism contributes to resistance to targeted therapies in breast cancer
Bryan Roth (UNC at Chapel Hill) – Exploring the subterranean biology of known drugs
Stephen Fesik (Vanderbilt University) – Cancer drug discovery using fragment-based methods and structure-based design
Brian Shoichet (UCSF) – A metabolic code for signaling
Stephen Frye (UNC at Chapel Hill) – Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers
Tom Kodadek (The Scripps Institute) – Chemical tools to monitor and manipulate the proteome
While there was a heavy emphasis on cancer research, there was plenty to take away from it for those working in other areas. Many of the techniques and approaches used were broadly applicable.
I was live tweeting the talks which can be found via Storify. In addition there was a poster session with 57 posters.
If this meeting had been more widely known it could easily have been twice the size and the organizers should be acknowledged for putting together a very informative session.
Translated with Google Translate