The panelists peered into a rapidly approaching future world where computers are doing experiments side-by-side with scientists. In that reality, having data that is FAIR (Findable, Accessible, Interoperable, and Reusable) is critical. The panelists reframed the way we think about our scientific legacy in terms of data as much as publications. The keys are providing ways to use the information provided from different experiments by people and computers.
We were delighted to discuss this future with Dr. Mark Musen (Stanford), who developed Protégé, a free, open-source ontology editor and framework for building intelligent systems, which is widely used to create formats for FAIR and reusable data. We also got to hear about Mark’s encore with CEDAR to make data more interoperable between related biomedical descriptions. Dr. Stephan Schurer (U. Miami) presented updates on Bioassay Ontology (BAO), Drug Target Ontology (DTO), and LINCS that allow data in the biomedical drug discovery space to be meaningfully organized. Finally, we were joined by CDD Advocate Dr. Janice Kranz who unveiled Bioassay Express, which allows non-computational scientists to more easily use these expert tools including a proof-of-concept on the >3500 MLPCN “Best of Pubchem” assays.
Lately there has been an emphasis on the quality of data for reproducibility, perhaps articulated most clearly in the drug discovery space via the Assay Guidance Manual which is a free, best-practices resource devoted to the successful development of robust, early-stage drug discovery assays.
The seeds have been sown for an era where computers are primarily handling scientific data and performing the analyses. People do not become an afterthought, but the types of experiments and data formats are considered in a new light.
What will research look like in 10-15 years? Get a sneak peak with the video above or slides below:
This blog is authored by members of the CDD Vault community. CDD Vault is a hosted drug discovery informatics platform that securely manages both private and external biological and chemical data. It provides core functionality including chemical registration, structure activity relationship, chemical inventory, and electronic lab notebook capabilities!
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