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Spotlight Interviews

Spotlight Interview with Dr. Andrew Calabrese – VP of Chemistry at AgriMetis

Dr. Andrew Calabrese - VP of Chemistry at AgriMetis
Going from academic research to industrial research, came with the realization that bulk data drives industrial research, whether its pharmaceuticals or agrochemicals. In academia you might focus in on a very specific issue and track data very carefully, on individual data points. In industry it's all about bulk data, and it's about drawing plots of multiple compounds vs multiple data points, and trying to find correlations and find the outliers and find the reason why compounds are doing what they're doing. CDD Vault is a great tool for bulk data analysis...
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CDD Spotlight Interview with James Moe – President, CEO and a co-founder of Oligomerix

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“We’re using CDD Vault as a way of storing our chemical structures, as a way of searching them, as a way of storing all of our assay data. We’re also using it for doing calculations, for analyzing our data, for creating reports and communicating the data to others, and then also, very importantly, for working…
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CDD Spotlight Interview with Ronnett Seldon, University of Cape Town, South Africa

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Interviewed by Collaborative Drug Discovery, Inc. When you joined H3-D were they already using CDD Vault?Yes, CDD Vault is a central database so everybody has access to the data. I have been with the project for 18 months now, and I run a dose-response inhibition assay which generates a significant amount of data analysis. I had intended to use GraphPad prism or Stata for my analysis in which I have to define controls and use a 4 parameter logistic regression for the curve generation. For large data sets, this takes a lot of time. I am a clinical research microbiologist, so I have a fair amount of experience with large datasets.While uploading data to CDD, I noticed in the help section of CDD Vault that the platform has a customized 4-parameter logistic regression that is used to process and analyze the data. This has changed, a whole lot and for the better, the amount of time I need to upload and process the data. CDD Vault is not just a database to which I bulk upload data, but I actually use it to analyze and process all my data...
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CDD Spotlight Interview with Thale Jarvis, Crestone Inc.

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"People sometimes refer to it as drug hunting. It starts with early discovery, finding interesting compound libraries and screening for hits, followed by a lot of intensive medicinal chemistry, microbiological and biochemical characterization and preclinical testing. Once you have an IND candidate, the focus expands to include process chemistry and toxicology testing. And that’s before you even consider human clinical trials. It’s a long process, but terrifically engaging. You have to balance optimism with realism. It takes great teamwork; to succeed, your team has to be smart, tenacious and lucky in about equal measures."
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CDD Spotlight Interview with Dale Cameron, viDA Therapeutics Inc.

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"It was the first time in my career that I can remember, where creativity and outside the box thinking allowed for mixing and matching a lot of different and unrelated tools, to do something they weren’t originally intended, to generate a result that had immediate and positive effect on our research programs. Completely unpublishable work, I must admit, but...our own crystal structures would eventually come sometime later in the program, and when compared to our hand-made model of a model, we were very close, to the point where the crystal structure simply validated our model, which for a computational chemist, was intensely satisfying."
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CDD Spotlight Interview with Enrique Michelotti, NIMH/NIH

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"I think the biggest impact was people in academia that were not used to databases and with the training and the use, they came to realize how powerful it is to have a permanent central repository, where you can access the data very fast and correlate the most salient patterns. I think that is the most important impact by providing this new capability that was even useful for people that were just not used to databases. It really speaks to the ease of use and overall design of CDD Vault."
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