CDD Vault Case Studies

ジュビラントバイオシス

jubilant biosys scientist pipetting Jubilant Biosys, a major international contract research organization (CRO), provides comprehensive drug discovery services to the global pharmaceutical industry. The company adopted CDD Vault and digitally transformed its data management, resulting in increased research productivity and customer satisfaction.

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GSK - Open Lab Foundation

GLAXOSMITHKLINE (GSK) has pioneered a model of true open partnership with academia through the Tres Cantos Open Lab Foundation, a ground-breaking PPP initiative set up at GSK’s dedicated DDW research facility at Tres Cantos in Madrid. Since its inception in 2011, the Tres Cantos Open Lab Foundation has managed more than 50 projects of drug discovery efforts against tuberculosis, malaria and kinetoplastid diseases (including trypanosomiasis, ie, African sleeping sickness and Chagas disease, and leishmaniasis). It is the world’s first open laboratory to investigate diseases of the developing world.

Read the full article published in Drug Target Review

Using CDD Vault to Manage Redbrick Molecular Ltd. Catalogs

Andy Hogben Redbrick

Redbrick Molecular has a rapidly growing library of novel building block and chemical scaffolds for medicinal chemistry from a variety of sources. They need to track compounds, properties, availability, and customer feedback in a secure database system that is easy for users. Andy Hogben tells us about their challenges and how they made use of CDD Vault to capture a complex catalog in a simple way.

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KINDReD Consortium

The FP7-funded Kinetoplastid Drug Development (KINDReD) consortium has been created to strengthen and advance the current drug development pipeline in neglected infectious diseases. The consortium's key objective is to bring promising anti-trypanosomatid drug discovery initiatives forward by combining the strengths of key experts in industry and academia to create a unique and powerful drug discovery platform with the common goal of advancing promising laboratory-driven discoveries into clinical utility.

The KINDReD consortium integrates leading academic laboratories in Europe (Portugal, United Kingdom, France and Switzerland), the USA (California), India and South America (Brazil) with high throughput screening (HTS) facilities equally distributed between all three major kinetoplastid parasites. CDD Vault is the collaborative data management platform used across all consortium members.

Acetylon Pharmaceuticals

Acetylon Pharmceuticals

This Harvard spinout company uses CDD Vault to manage both academic-industry and China CRO collaborations. After becoming a customer in 2009, they have grown to a dozen CDD Vault users presently, all while filing for an IND for their HDAC inhibitor and raising $27M in a Series-B financing and a partnership with Celgene ($100M upfront cash).

NIH Blueprint

The NIH Neuroscience Blueprint licenses CDD Vault across 7 leading academic laboratories, 4 CROs (including CDD), and ex-pharma drug development consultants. Their collective historical data was loaded into CDD Vault within one month, allowing them to work as a “virtual pharma” to develop compounds from chemical optimization through Phase I clinical testing.

Read the CDD Spotlight Interview with Enrique Michelotti, NIMH/NIH

UCLA

UCLA's screening center uses CDD Vault to support all campus-wide collaborations. In addition, The Center for Medical Countermeasures against Radiation (CMCR) uses CDD Vault as part of their multi-institution consortium to develop small molecule radiation mitigators.

Read the UCLA case study

Mironid Ltd

Mironid lead screening using CDD Vision Mironid is a biotech company that embraced the distributed research model with multiple physical sites and CRO collaborations. By implementing a hosted informatics platform early on, Mironid was able to ensure effective data management and sharing across the team and rapid advancement of several hit compounds for optimization.

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Bill & Melinda Gates Foundation

In support of the foundation's pursuit of collaborative research on tuberculosis, CDD Vault is used by 250 researchers across 58 laboratories. Twenty different collaborations between teams have been enabled to securely share their data, and for this, CDD Vault won the BioIT World Editor's Choice Best Practices Award.

Read about the award this study won

International Anti-Malarial Collaboration

An ad hoc collaboration was established to evaluate anti-malarial compounds for the growing challenge of chloroquine resistance. A virtual screen was performed using CDD Vault with contributions from four independent groups across two continents. The most promising candidate compounds were assayed, and novel compounds that almost entirely reversed the resistance were identified. This process shaved months to years off a project relative to working independently and/or synthesizing new compounds from scratch.

viDAセラピューティクス

Design and development of new drugs is a difficult endeavor. Small companies can spend a large amount of time just managing data and communicating results, let alone on scientific innovation and finding new candidates for development. viDA Therapeutics was one such company, and their use of Excel files to track their important chemistry and biology data lacked transparency, control and efficiency. By implementing CDD Vault, they achieved better control of data, vastly improved collaboration, and the ability to track diverse data types (chemistry, biology, pharmacology, structural biology/X-ray, patents, etc.).