Bios for CDD Town Hall: Optimal Library Selection for Drug Discovery


Bios for CDD Town Hall: Optimal Library Selection for Drug Discovery



Michelle Arkin, Ph.D.
Associate Professor, Pharmaceutical Chemistry
Director, Biology, Small Molecule Discovery Center
University of California, San Francisco

Michelle
Michelle Arkin is an Associate Professor of Pharmaceutical Chemistry and the Director of Biology at the Small Molecule Discovery Center at UCSF. The Small Molecule Discovery Center is a research ‘colaboratory’ that works with academic and biotech investigators to develop small-molecule probes and drug leads. Michelle’s research is focused on structure/function and chemical biology of allosterically regulated enzymes and protein-protein interactions (PPI). Her lab also has a strong interest in developing probes and drug leads to address mechanisms of neurodegeneration, cancer, and parasitic disease. Michelle is involved in academic drug discovery as an investigator in the NCI’s Chemical Biology Consortium and the Tau Consortium, an editor of the NIH’s Assay Guidance Manual, and a board member of the Academic Drug Discovery Consortium.


Nick Skelton, Ph.D.
Principal Scientist
Genentech

Nick
Nick Received his Ph.D. from Cambridge University and was a post-doctoral fellow at The Scripps Research Institute before joining Protein Engineering Department Genentech in 1992. His initial research focused on structural biology of proteins, peptides and their interactions. In 2004 he moved to the Discovery Chemistry Department and has focused on using computation to support therapeutic area projects, building Genentech’s screening libraries and exploring novel lead-finding approaches for hard-to-drug targets.



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