The first Tuberculosis drug in 40 years!
The FDA just last week approved the first new treatment for tuberculosis in 40 years, Bedaquiline (also known as Sirturo, TMC207 or R207910).
This drug was discovered via the screening of 70,000 compounds for activity against M smegmatis, a more rapidly growing and manageable mycobacterium compared with M. tuberculosis.
Clifton Barry, a leader in the field of TB drug development, gives an interesting review of how this drug was discovered “the wrong way”.
This blog is authored by members of the CDD Vault community. CDD Vault is a hosted drug discovery informatics platform that securely manages both private and external biological and chemical data. It provides core functionality including chemical registration, structure activity relationship, chemical inventory, and electronic lab notebook capabilities!
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