Barry Bunin, Ph.D.
CEO and Board Director
Barry A. Bunin, Ph.D. is the CEO of Collaborative Drug Discovery. Dr. Bunin has overseen $75 million in business transactions over the last two decades. Prior to CDD, he was an Entrepreneur in Residence with Eli Lilly & Co. Dr. Bunin is on a patent for Kyprolis™ (Carfilzomib for Injection) — a selective proteasome inhibitor that received accelerated FDA approval for the treatment of patients with multiple myeloma that was widely viewed as the centerpiece of Amgen’s $10.4 Billion acquisition of Onyx Pharmaceuticals.
Dr. Bunin was the founding CEO, President, & CSO of Libraria (now Eidogen-Sertanty). At Libraria, he led a team that integrated exhaustive reaction capture (synthetic chemistry) with gene-family wide SAR capture (medicinal chemistry). On the scientific side, he co-authored “Chemoinformatics: Theory, Practice, and Products” (Springer-Verlag), a text that overviews modern chemoinformatics technologies, and “The Combinatorial Index” (Academic Press), a widely used text on high-throughput chemical synthesis.
In the lab, Dr. Bunin did medicinal synthetic chemistry developing patented new chemotypes for protease inhibition at Axys Pharmaceuticals (now Celera) and RGD mimics to inhibit GP-IIbIIIa at Genentech. Dr. Bunin received his B.A. from Columbia University and his Ph.D. from UC Berkeley, where he synthesized and tested the initial 1,4-benzodiazepine libraries with Professor Jonathan Ellman.
Sylvia Ernst, Ph.D.
Sr. Manager, Commercial Operations
Dr. Sylvia Ernst is a respected figure in the business realm of chemical information technology, bringing her global business experience to the leadership team at CDD.
Since joining CDD in 2007, Dr. Ernst has played a pivotal role in shaping the company’s success. She is driven by the steadfast belief that leveraging technology for collaboration, paired with robust data management, can greatly expedite the discovery of new therapies. Her work ranges from customer-facing roles to operational ones, facilitating strategic partnerships and negotiating impactful contracts.
In her past roles at Accelrys, SciTegic, Elsevier MDL, MDL Information Systems, and Beilstein, Dr. Ernst honed her expertise in customer-centric and management roles.
She earned her Ph.D. in Chemistry at J. W. Goethe University Frankfurt in Germany under the esteemed Prof. Dr. Wolfgang Kaim. With over 20 scientific publications to her name, Dr. Ernst's early research focused on the innovative use of computational chemistry to discover new catalysts for generating hydrogen from water and sunlight.
Director of Product Excellence
Kellan Gregory is CDD's Director of Product Excellence. He has a degree in Chemical Engineering with an emphasis in biotechnology from Tufts University. Kellan was co-author in an HIV study with Dr. Paul A. Volberding, and interned with BioRad and Libraria.
He has not written two books and founded two companies like Barry Bunin, PhD. Unlike Sylvia Ernst, PhD, he did not help with commercial introductions of both Beilstein and Pipeline Pilot. And he’s at least 50 publications behind Alex Clark, Ph.D.
But you know what? If you want a product expert with the most experience using data and databases, the strongest people skills and the ability to tell you straight up what will and will not work, Kellan Gregory – with his growing team of specialists in the product group – is your best collaborator. Kellan also creates practical specifications for our product enhancements by prioritizing thousands of requests from hundreds of CDD customers.
Head of Operations EMEA/LATAM
Dr. Vaschetto drives our global collaborations from CDD’s new European Office. Previously she was the VP of Strategic Partnerships, Sales, and Marketing at Dotmatics and held similar executive roles at Perkin Elmer (previously CambridgeSoft). Mariana’s broad experiences span across informatics, chemistry, physics, biology, and communication fields.
She rose through the ranks at Accelrys from responsibilities for support to informatics applications to Chemoinformatics Software Product-Marketing Manager to Senior Product Manager for their complete product line (including data content and software).Mariana has a flair for cooking and knows which way the wind is blowing. Her PhD is in Chemistry.
Chief Technology and Security Officer
Krishna Dole has a decade of experience creating collaborative scientific software. He has developed software for drug discovery, population biology, geomorphology and phylogenetics. Prior to joining CDD in 2007, he coauthored mx, an open source biodiversity informatics application that remains under active use and development.
On the software side, he has been working with the Ruby on Rails framework for over 6 years, and has published a plugin and submitted bugfixes to Rails itself. Like all of CDD's software developers he is an enthusiastic user of automated testing, the agile process, and behavior driven development. At CDD he draws on his broad experience to guide the design and implementation of scientific features. Krishna has a double BA in Biology and Earth Sciences/Environmental Studies from UC Santa Cruz.
Alex Clark, Ph.D.
Alex Clark has been building cheminformatics and computational drug discovery software products since the early 2000's, after spending a decade learning to be a scientist the hard way: running reactions at the lab bench.
Since switching to informatics full time, he has worked on most areas of contemporary chemistry software, whether it be 2D or 3D, large scale (cheminformatics) or small scale (quantum chemistry), big molecules (proteins) or small molecules (drugs). He has a persistent interest in the interface between scientists and software, which continues to challenge our industry, and has done much work on visualization techniques, electronic lab notebooks, and reimagining traditional software for new platforms like mobile, cloud and web.
He publishes regularly in the scientific literature, and has maintained a large number of collaborations since becoming an entrepreneur in 2010. Whenever he is not working on projects for CDD, he continues to maintain his own company, Molecular Materials Informatics, relentlessly experimenting with all manner of future-oriented chemistry software ideas, methods and products. Alex completed his doctorate at the University of Auckland, New Zealand, in 1999, and subsequently relocated to North America.
Director of Customer Engagement
Charlie Weatherall is CDD's Director of Customer Engagement. He attributes his extreme customer dedication to two things. First, he is a true Southern gentleman who cares greatly about other people. Second, he started his career as an R&D end-user of multiple scientific applications and has never forgotten what it's like to "be the customer."
Charlie has over two decades of experience working with industry-leading scientific software companies such as MDL (dating back to ISIS version 0.9 in ’91), SciTegic, Accelrys, CambridgeSoft, and IDBS. He has traveled extensively installing software, providing training, and leading workshops at customer sites and conferences. Customers throughout the world (including Japan, Australia, Great Britain, France, New Jersey, and Illinois) have been known to alter their schedules to match Charlie's availability for visiting their sites. Charlie is looking forward to being the best customer advocate and trusted advisor for the CDD community.