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    November 21, 2022

    Collaborative Drug Discovery Announces New NIH Grant to Develop Intelligent Chemical Structure Browser

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    The $1.45 million grant from National Center for Advancing Translational Sciences will allow CDD to develop an intelligent chemical structure browser

    Burlingame, California - November 21, 2022 - Collaborative Drug Discovery has received a $1.45 million grant from National Center for Advancing Translational Sciences to develop intelligent chemical structure browser for drug discovery.

    Collaborative Drug Discovery, Inc. (CDD) proposes to develop a novel intelligent data browser that will enable medicinal chemists developing new drug compounds to more efficiently browse and organize experimental data in an intuitive way. The proposed browser will essentially "hyperlink" chemical space and allow chemists to navigate easily among compounds in a chemical lead series following the same pathways that lead from one compound to the next in the mental models that they intuitively map in their heads. Navigating through and extending a lead series to discover the optimal drug candidate to advance into animal studies and clinical trials comprises a critical stage of the drug discovery pipeline: the success of large subsequent investments depends on making the right decision. This stage also especially emphasizes creative and intuitive thinking. Existing software that assists scientists engaged in this task tabulates data in formats that make it difficult to assemble and compare the essential data needed to rapidly explore ideas about how to further optimize promising candidates.

    Example of a few hypothetical molecules

    Our proposed intelligent browser will support more natural and intuitive workflows. A key enabling innovation for this technology is a methodology that we have developed to organize molecular structures through a partial ordering based on the substructure-superstructure relation as a Hasse diagram. Our semilattice representation provides a machine computable format that can capture the relationships among related chemical entities that a medicinal chemist intuits. Expected key impacts include (1) faster development of lead series into drug candidates, (2) cost savings due to more efficient use of synthesis and assay resources, and most importantly (3) better scientific decisions about which compounds to pursue and advance into the clinical pipeline. Better decisions at this stage in the drug discovery process should increase the probability that drug candidates that are chosen will successfully emerge through the clinical pipeline as FDA approved drugs, and improve the effectiveness and safety profile of those drugs. Even a small increase in these probabilities multiplied by the size of the investments required to take drugs through clinical trials translates into a large value. We have validated this perception of value in preliminary market research with potential pharmaceutical company customers.

    Composite of several screens from a preliminary UI Mock-up

    About Collaborative Drug Discovery, Inc.

    CDD's (www.collaborativedrug.com) flagship product, "CDD Vault®", is used to manage chemical registration, structure-activity relationships (SAR), and securely scale collaborations. CDD Vault® is a hosted database solution for secure management and sharing of biological and chemical data. It lets you intuitively organize chemical structures and biological study data, and collaborate with internal or external partners through an easy to use web interface. Available modules within CDD Vault include Activity & Registration, Visualization, Inventory, and ELN.

    A complete list of more than 60 publications and patents from CDD can be found online on our resources page at https://www.collaborativedrug.com/publications-and-resources/.

    Media Contact: Barry Bunin, Ph.D., Collaborative Drug Discovery, marketing@collaborativedrug.com.

    Tag(s): CDD Blog , News

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