In this update we have changed the way numbers with modifiers (that is: >, <, ≥ and ≤) are aggregated. Numbers with modifiers are also referred to as bounded values, and this will mainly affect averages of IC50 measurements. The rule can be stated as: a bounded value will not be included when computing the average if there is another measurement that is consistent with it and is more specific. Exact values are always included.
- Less specific bounded values are not included: Average(<1, <10) = <1 Average(20, 30, <100) = 25 Average(80, <100, 150) = 115 (<100 is consistent with 80 and less specific)
- Bounded values are retained if they are not consistent with an exact value: Average(<2, 8) = <5
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