<img height="1" width="1" style="display:none;" alt="" src="https://px.ads.linkedin.com/collect/?pid=384506&amp;fmt=gif">
Skip to content
Book a Demo
    November 10, 2011

    New data released: Trypanosomal phosphodiesterase inhibitors.

    A new public data set has been released from the neglected disease drug discovery team at Northeastern University (Boston, MA) and the Marine Biological Laboratory at Woods Hole, as reported in the Journal of Medicinal Chemistry this week (DOI: 10.1021/jm201148s). This data set consists of a range of established human phosphodiesterase inhibitors, tested for inhibition against the phosphodiesterases B1 and B2 of Trypanosoma brucei.

    The Laboratory for Neglected Disease Drug Discovery at Northeastern University will publically release compound structure and biological activity data as a matter of course immediately upon publication. Research projects primarily employ a target repurposing approach, wherein essential pathogen targets are matched with proven druggable human homologs. The pathogen targets (or the pathogens themselves) are tested for susceptibility to established inhibitors of the human homologs, providing a potential starting point for optimization of new anti-infective agents, or even opportunities for direct repurposing of existing drugs.

    For more information, contact Mike Pollastri at Northeastern University (m.pollastri@neu.edu), or check out the laboratory website: http://www.northeastern.edu/pollastri/.

    Tag(s):

    Other posts you might be interested in

    View All Posts
    Webinars
    1 min   September 30, 2025
    AI-Driven Drug Discovery to Address Antimicrobial Resistance and Glioblastoma: Stoked Bio's MOSAIC Platform Approach
    Read More
    CDD Vault Snack
    4 min   September 29, 2025
    Vault Snack #31 – Chemically-Aware Antibody and Antibody Drug Conjugate (ADC) Registration
    Read More
    CDD Vault Updates
    2 min   September 25, 2025
    CDD Vault Update (Sept #4 2025): Publication Ready Plots and ELN to Inventory Connections
    Read More